Thursday, November 28, 2019

An Investigation into the effect of Temperature on the release of Betalain from Beetroot Tissue Essays

An Investigation into the effect of  Temperature on the release of  Betalain from Beetroot Tissue Essays An Investigation into the effect of  Temperature on the release of  Betalain from Beetroot Tissue Essay An Investigation into the effect of  Temperature on the release of  Betalain from Beetroot Tissue Essay The aim of this investigation is to see what if any affect temperature has on the release of Betalain from beetroot tissue. To carry out this investigation I am going to need the following equipment and materials. Apparatus Electric water bath This will be needed to keep the water temperature consistent throughout the experiment at the various required temperatures. Thermometer This will be used to check that the water bath is heating accurately at the required temperatures throughout the investigation. Colorimeter This is what will measure the affect that the heat has on the membrane by measuring how much light passes through the solution. These are the apparatus that will be used to heat and record the data but in order to use these other apparatus must be used too; Test tubes Syringe (to accurately measure the fluid amounts) Cork borer (to shape the beetroot equally) Curettes Measuring cylinder Scalpel Materials Beetroot Distilled Water Method Cut out three pieces of beetroot about 2cms long using a cork borer. Place the cylinders of beetroot on a tile or board and using the scapulae cut into discs 5mm thick. Label 3 test tubes, A B C for each of the temperatures to be tested. The temperatures required are 20, 30, 40, 50, 60, 70 and 80à ¯Ã‚ ¿Ã‚ ½c Put 10cmà ¯Ã‚ ¿Ã‚ ½ of distilled water in each test tube Place the three test tubes for the required temperature in the water bath and heat to the required temp if needed Check the required temp has been reached using the thermometer to measure both the water bath and the test tubes temps Place the three pieces of beetroot in the three test tubes and leave for two minuets After the time is over remove the test tubes from the water bath and using the syringe which should be clean, extract 5cl from each solution to fill up a curette for each which should also be labelled, check no pieces of beetroot are in the curette Set the Colorimeter to 0 % transmission with water Make quantitative measurements using the colorimeter and record for each Repeat method for each of the temperatures Variables INPUT Temperatures, 20, 30, 40, 50, 60, 70 80 CONTROL Beetroot size/shape, beetroot type (use same beetroot), pH amount of the water, temperature consistency, time in waterbath OUTPUT Rate of diffusion measured using colorimeter to measure concentration of dye (Betalain) in solution Explanation My input variable will be the temperature. This will be held at constant temperatures by the water bath and the temperatures changed consistently. The water temperature needs to be held consistently while the diffusing is taking place so that the rate isnt affected and it is a fair test. My control variables will be controlled in the following ways. The size/shape of the beetroot will be controlled by the cork borer and by measuring its length. This has to be done and it is important that it is done accurately because the volume to surface area needs to be the same. This is needed so the rate of diffusion is the same for each piece of beetroot before the temperature is changed. Beetroot type will be the same because I intend to use the same Beetroot unless I run out! The Beetroot will be left covered while not being used and the only pieces to be cut from it will be the ones for the temperature, which will be measured next. This will prevent any of the beetroot drying up as if the membranes dry up they will release less Betalain. It will also prevent any individual differences between the beetroots affecting the results. Distilled water will be used so as to keep the pH of the water the same. The pH needs to be consistent because it will affect the rate of diffusion, for instance a high acidic pH would denature the proteins in the membranes and completely compromise the results. The temperatures will be kept constant by the water bath as explained in the input. Output Data will be recorded by the rate of diffusion. This will be the rate at which the Betalain will have diffused from the beetroot to the solution over the given amount of time. This will be measured by the transmission of the water as read by the colorimeter. This will give an accurate reading of how great the concentration of the dye in the water will be. This can be used to work out the rate of diffusion by dividing the transmission % of the solution by the time given for the diffusion to take place. % / Time = Rate of Diffusion This is assuming the pigment release is constant Equipment Details Colorimeter, device used to compare or measure colours and their intensities. A simple colorimeter uses an optical system to place an unknown colour, such as of a chemical sample, next to a well-established colour. In more advanced devices this comparison field can be adjusted in various quantifiable ways. In some, photoelectric cells may be used to measure the transmitted light. Colorimeters are used in chemical research and in various industries, such as the manufacture of dye and paint. The Colorimeter is the best way to measure the diffusion rate with the equipment, which we have available to us. There are not many other alternatives and using eye site to measure colour would be very in accurate. The Colorimeter is very accurate providing it is set first for water having 100% transmission. It is a reliable piece of equipment, which is well suited to this investigation. Electric Water Bath, heats water to a required temperature and then maintains this temperature for as long as required. This is the best piece of equipment to use to get reliable, constant temperatures throughout the investigation. It can heat to exactly the required temperature and hold it whist the beetroot is placed in the test tubes. This would not be possible with a Bunsen Burner. The Thermometer will be used to check the reliability of the water bath. The syringe will be used to get an accurate amount of distilled water in the test tubes and then will be used to distract the solution afterwards without beetroot and placing it in a curette. The cork borer will be used to shape the beetroot consistently as explained in the method and variables. The scapulae will be used to cut the shaped beetroot into the right size and the curettes are what the colorimeter uses to read the transmission of the solution. Method Details I am going to use the following temperature ranges to collect my data; 20, 30, 40, 50, 60, 70 ; 80à ¯Ã‚ ¿Ã‚ ½C. I have decided to use these to give me a valid and reliable set of results to analyse and draw graphs and conclusions from. I intend to start at 20à ¯Ã‚ ¿Ã‚ ½C because this is the normal temperature of Beetroot and will give me a good basis to work from. Not only will this give me readings for the investigation at normal temperatures but with the equipment available to me it is the lowest temperature I am willing to go to. Going lower would mean having to use ice, which I dont intend to use as it would be very hard to keep constant and may impeded the results. I that two minuets should be sufficient for the diffusion to take place as Beetroot releases a large amount of betalain under normal conditions when cut. I feel that once in heated water or even in water at room temperature within two minuets enough betalain should have diffused for relevant data to be collected. I am also worried that if the Beetroot is left to long the rate of diffusion will slow and that the time taken to reach this point will decrease as the temperature increases. This would not help as my formula for working out the rate of diffusion, (transmission / time) is dependent on the pigment release being constant. I feel that allowing only two minuets for the diffusion will avoid this happening. The data collected will be taken from the solutions after the two minuets is up. The syringe, which should be clean so as not to affect the solution, will be used to extract 5cl from the solution. This will then be put into a curette, and its transmission measured by the colorimeter. No bits of Beetroot should be in the solution as this could show up on the readings. The transmissions will be recorded in a results table. These will be recorded as percentages as that is how the colorimeter reads them. They then need to be recorded as their rate of diffusion using the formulae. Each of the three rates for each temperature need then to be added up and given as an average. This is done to avoid anomalous results. if there are any outstanding anomalies then they should be removed before the averages are worked out. After the averages have been recorded graphs can be drawn up and then analysed for correlation or anomalous results. Scientific theories can then be used to explain the results and then conclude the investigation. Changes in Method There were some problems whilst collecting the results which may have an affect on the findings from them. Firstly was with the temperatures of the water baths which we heated the beetroot in; these were less reliable than I had hopped as far as keeping the water at a consistent temperature. They could not hold the water at exactly 35à ¯Ã‚ ¿Ã‚ ½C, 45à ¯Ã‚ ¿Ã‚ ½C, 55à ¯Ã‚ ¿Ã‚ ½ or 65à ¯Ã‚ ¿Ã‚ ½C etc so temperatures were recorded from around the right temperature, and that temperature recorded with them. I would also have liked the water baths to be as consistent as possible but Im not sure they were as once they reached the required temperature they turned off. This may mean that the temperatures varied slightly over the five minuet period the beetroot was left to diffuse, however I still feel that the temperatures recorded are varied enough and close enough to the original aims to still be used to analyse and solve the problem. The Colorimeters readings may also have an affect on the results. This is because they did not always read consistently. This could be because of smudges on either on the curettes or on the lens or perhaps due to the particles moving around in the solution. I feel, however that the data collected has been accurate enough and varied enough to analyse and solve the problem fairly. I also found that two minuets did not prove a sufficient amount of time for the diffusion to take place, and so I extended the time to 10 minuets. This is because I found that I had underestimated the rate of diffusion from the beetroot and that after just 2 minuets not very much dye had diffused at all and comparisons would be small. By leaving the Beetroot longer it allowed more Betalain to diffuse and a wider range of results to work with. Analysis of original Results The original set of results look quite promising. I have used the colorimeter to obtain data for; absorption, transmission and the rate of reaction. The absorption and transmission are readings given by the colorimeter and can be used to work out each other. The formula to use to work out the transmission from the absorption is to take the absorption from 100 to get a percentage for the transmission of the colorimeter reading. And this is the formula I have used in my results table (100-a) which was created using Microsoft Excel. The next figure in the table is the Rate of Diffusion per Minuet, which is the figure I intend to use to analyse my findings with. This is worked out by dividing the absorption by 5, (a/5) the amount of minuets the beetroot was left for (this is presuming the diffusion rate was consistent). This then relates directly back to the problem which asked how temperature affected the rate of diffusion of betalain from beetroot to water over a given amount of time. I have recorded all three of these in the table for each of the temperatures implemented and for all five repetitions I have then added them and divided by five to give an average. I have also included the size of the beetroot in mm (length multiplied by diameter), the weight of the beetroot in grams, the volume of water from the test tube and the time in minuets. These are all control variables but I have included them in the table so all relevant stats are visible and they can be shown as consistent. There are however some anomalous looking results, I have highlighted these results red but have not removed them yet. I will draw up a graph first and analyse the results further before deciding if these results are having to much of an effect on the averages to be included in the findings. Analysis The graph has used the rate of diffusion per minuet results from the results table. The calculation for this is the absorption rate divided by five; the amount of minuets the beetroot was left for. This gives you the amount a figure for the amount of diffusion taking place every minuet presuming the diffusion is consistent. The graph shows a clear positive correlation for greater heat, greater release of Betalain. This would be because the hotter the Betalain gets the more energy its molecules will get and the more motion they will make and the more will diffuse through the membrane of the beetroot and into the water. However there is a large range in the error bars on most of the results and some overlap. I feel this could be because of the results I highlighted in the table I am therefore going to redo the table without these anomalies and see if I can improve the quality of the graph and findings. Edited Results Temp (à ¯Ã‚ ¿Ã‚ ½C) Figure Repeat 1 Repeat 2 Repeat 3 Repeat 4 Repeat 5 Average 25 Rate %minà ¯Ã‚ ¿Ã‚ ½Ãƒ ¯Ã‚ ¿Ã‚ ½ 3.2 2.2 3.8 3.2 3.2 3.12 35 Rate %minà ¯Ã‚ ¿Ã‚ ½Ãƒ ¯Ã‚ ¿Ã‚ ½ 4.2 4.4 4 4.6 4.4 4.32 45 Rate %minà ¯Ã‚ ¿Ã‚ ½Ãƒ ¯Ã‚ ¿Ã‚ ½ 4.6 5.2 5 6.4 6 5.44 55 Rate %minà ¯Ã‚ ¿Ã‚ ½Ãƒ ¯Ã‚ ¿Ã‚ ½ 10.8 13 11.2 10 12.4 11.48 65 Rate %minà ¯Ã‚ ¿Ã‚ ½Ãƒ ¯Ã‚ ¿Ã‚ ½ 14 14.2 14.6 15.4 15 14.64 I have removed the anomalies and used the average of the other four readings for that temperature to fit the Excel formula. This has given me more consistent results and should help to get a better correlation on the graph for my final readings. I have also removed the Absorption and Transmission readings from the table to make it more condensed and easier to read and evaluate. I decided that in this table only the essential figures should be kept in, the ones that I will be using to create my final graph with. Therefore I have gotten rid of the size, weight, water volume and time as these are all consistent and do not need to be present on the graph. Analysis Removing the main anomalies from the results has made the graph look more accurate and more relevant. There are smaller error bars and the results are in a better correlation. The only Results not closely corallined are those for 55à ¯Ã‚ ¿Ã‚ ½C but because these results were so varied that picking out anomalies would not work here. The line on the graph is more of a steeper gradient and would form an S shape if I were to draw a line of best fit on it. Conclusion and Background Information I can now conclude that the relationship between heat and diffusion on a beetroots membrane is that the greater the heat, the greater the rate of diffusion. This is as I expected and of no great surprise. The main reason for this would be because the greater the heat, the greater the energy the Betalain molecules would have and the more motion they would have. This would lead to more diffusing in a shorter amount of time. The cell membranes main function is to serve as a boundary between the cell and its environment. It is just like other organelles in the cell in that it serves the cell by having its own specialised jobs. In terms of beetroot the Betalain is contained within the cell membrane, if this membrane is broken or disrupted the pigment will be released. Temperature may be the cause of the disruption. High temperatures could distort the active site of the carrier, channel of gated proteins, therefore affecting the shape of the fluid mosaic model membrane which may release the betalian or other molecules held inside the beetroot. Temperature can also affect the rate at which the diffusion takes place by giving the particles more energy. I feel that this is more likely to be what caused the higher rate of diffusion rather than the disruption which was caused by cutting the beetroot up. This has been shown on the graph and in the results and I can now conclude that the higher the temperature of the water and Beetroot the higher the rate of diffusion will be over the semi permeable membrane. Evaluation The Problem has been solved and even though there were anomalies and some of the equipment was perhaps not as accurate as would have been preferred the experiment has been a success and there can be no doubt of the effect on heat on the rate of diffusion of Betalain between the membrane of a beetroot and water. There were limitations with the amount of equipment we could use and on methods we used as we only had the schools supply of equipment and only two lessons in which to collect data. The first of which and perhaps the most important of which was the water bathes. Water Bathes These were supposed to keep a level and consistent temperature throughout the duration of the experiment. This however they did not do, they did not reach the required temperatures very well and there gages often read differently to the thermometers used to back them up. Also once the required temperature or at least what the water bathes considered as the required temperature was reached, the water bathes shut themselves off. There would then be no heat or buffer to keep the temperature constant. Whilst this is a much more effective and accurate way of reaching the temperatures and conducting the experiment than using Bunsen burners or any of the other equipment the school could have provided, it was a bit disappointing that it couldnt hold its temperature. The poor precision of the water bathes could have had an effect on the data recorded. The experiments were supposed to be conducted at 25, 35, 45, 55 and 65à ¯Ã‚ ¿Ã‚ ½C but the real temperatures were from around these temperatures. This could have led to variation in the in the in the data collected as some of the error bars were quite large, for instance the changing temperatures could mean that once you returned to repeat the experiment the water bath would be at a different temperature to when you first recorded the results. Another factor affecting the difference in results could the position in the water bathe, if two different thermometers (the water bathes thermostat and the separate thermometer) are reading different temperatures then maybe the temperature isnt consistent throughout the water bathe at the same time. If one test tube was placed directly above the heater and another away from it they would have different temperatures leading to a deviance in the results. This lack of reliability may have had an effect on the conclusions as well as the results. On the first graph the error bars were clearly to large and needed editing to remove the anomalies and redo a more consistent line. The figures used for the graphs were suppose to be for the rate of reaction and to work this out the diffusion should have been constant, but if the temperatures werent constant then its probable that the diffusion wasnt either. This could not be helped though and differences although there were some anomalies were fairly consistent and showed enough reliability to be analysed, concluded and explained using Biological Knowledge.

Sunday, November 24, 2019

Free Essays on Nightclub Plan

Table of Contents Topic Page # „h Executive Summary 4 „h Mission Statement 8 „h Description of the Venue 10 Company Summary 11 Start-up Summary 12 Business Description 15 „h Market Analysis 16 Market Analysis Summary 17 Market Segmentation 18 Chart 1  ¡V Total UCONN Enrollment 19 Demographic Statistics 20 Target Market Segment Strategy 23 Service Business Analysis 26 Main Competitors 27 Strategy and Implementation Strategy 30 „h Marketing Plan 32 Marketing Strategy 33 „h Operations Plan 35 Personal Plan 36 Management Summary 40 Management Team 40 „h Financial Plan 44 Income Statement 2002 46 Income Statement 2003 47 Income Statement 2004 48 „h Appendices 49 Advertisements 50 VIP Passes 51 Executive Summary The Mecca Nightclub will be a premier, high-energy, theme dance and nightclub located in Mansfield/Storrs, Connecticut. Our goal is to provide college students with the best nightclub experience with quality service at a reasonable price. The atmosphere of high energy, light and sound systems mixed with interactive theme nights will give club goers exceptional entertainment. Our objective is to establish a brand of entertainment and service that is unique and adds more value than any other alternative. Based on our investigations not many businesses will compete against us, thus giving our product the upper hand in our market niche. Our operating motto: MECCA - Make Every Customer Come Again, and leave a lasting impression in our customer ¡Ã‚ ¦s minds. The Mecca is a partnership business owned by six entrepreneurs: „h Anthony DiGiacomo  ¡V ... Free Essays on Nightclub Plan Free Essays on Nightclub Plan Table of Contents Topic Page # „h Executive Summary 4 „h Mission Statement 8 „h Description of the Venue 10 Company Summary 11 Start-up Summary 12 Business Description 15 „h Market Analysis 16 Market Analysis Summary 17 Market Segmentation 18 Chart 1  ¡V Total UCONN Enrollment 19 Demographic Statistics 20 Target Market Segment Strategy 23 Service Business Analysis 26 Main Competitors 27 Strategy and Implementation Strategy 30 „h Marketing Plan 32 Marketing Strategy 33 „h Operations Plan 35 Personal Plan 36 Management Summary 40 Management Team 40 „h Financial Plan 44 Income Statement 2002 46 Income Statement 2003 47 Income Statement 2004 48 „h Appendices 49 Advertisements 50 VIP Passes 51 Executive Summary The Mecca Nightclub will be a premier, high-energy, theme dance and nightclub located in Mansfield/Storrs, Connecticut. Our goal is to provide college students with the best nightclub experience with quality service at a reasonable price. The atmosphere of high energy, light and sound systems mixed with interactive theme nights will give club goers exceptional entertainment. Our objective is to establish a brand of entertainment and service that is unique and adds more value than any other alternative. Based on our investigations not many businesses will compete against us, thus giving our product the upper hand in our market niche. Our operating motto: MECCA - Make Every Customer Come Again, and leave a lasting impression in our customer ¡Ã‚ ¦s minds. The Mecca is a partnership business owned by six entrepreneurs: „h Anthony DiGiacomo  ¡V ...

Thursday, November 21, 2019

Critical Review of Nelson Mandelas Autobiography, A Long Walk to Essay

Critical Review of Nelson Mandelas Autobiography, A Long Walk to Freedom - Essay Example Along with his peers, Mandela was inculcated with a tremendous sense of responsibility to his family and community. This is evident from his statement, "at night, I shared my food and blanket with these same boys. I was no more than five when I became a herd-boy, looking after sheep and calves in the fields." The important element that contributed to the political consciousness of Mandela during his youth was his listening to the elders of his village discuss the history of their people. "It was from Chief Joyi that I began to discover that the history of the Bantu-speaking peoples began far to the north continent." He learned much about some of the atrocities experienced by his people under European colonial rule and this began to shape his consciousness. Mandela's desire to study law emanated from his observations of the paramount chief conducting court in his village and from his commitment to helping to end minority rule in South Africa. "My later notions of leadership were prof oundly influenced by observing the regent and his court. I watched and learned from the tribal meetings that were regularly held at the Great Place". Mandela's initiation into political activism began in 1940 while he was working on his degree at Fort Hare College in the Eastern Cape. He did well academically but he began to realize himself as 'the other'. "We were taught -- and believed -- that the best ideas were English ideas, the best government was English government, and the best men were Englishmen. " Such education persuaded him to forge an identity of his own. As a member of the Student's Representative Council, he was suspended from school for participating in a boycott to protest the reduction of the council's powers by authorities. After returning home briefly, he soon left for Johannesburg to avoid an arranged marriage and being trained for chieftainship. The events that occurred here are important as they shape Mandela's views about segregation. While working as a mine policeman, he observed, "the mining companies preferred such segregation because it prevented different ethnic groups from uniting around a common grievance and reinforced the power of the chiefs." During this period, the early 1940's, Mandela became politically aware and joined the African National Congress (ANC), a middle-class political movement founded in 1912. Chafing at the ANC's ineffectiveness in getting the government to recognize African rights, he helped launch its Youth League in 1944. Four years later, the Afrikaner-dominated National Party's rise to power began the apartheid era and made ANC activities more urgent. In the early 1950s he initiated the defiance campaign' against the discriminatory policies of the South African government, and argued for non-violent resistance to apartheid. However, following the Sharpeville massacre in 1960 his position changed, and he was forced underground to avoid the newly-imposed ban on the ANC. The horrors at Sharp eville hardened Mandela's resolve, and he began to advocate a different course of non-terrorist' action, aimed at the state but theoretically preventing civilian unrest. He was appointed the campaign's national volunteer-in-chief, which required that he travel throughout South Africa visiting the many black townships in order to explain and win mass support for the campaign.

Wednesday, November 20, 2019

Compare the food with The book Omnivore's Dilemma Research Paper

Compare the food with The book Omnivore's Dilemma - Research Paper Example However, most health experts have warned against eating processed food. This is due to the health risks associated with processed food. For instance, most Americans are over obsessed with eating fast foods such as humbugger prepared in famous restaurants such as McDonalds. Before the humbugger comes to the table, it undergoes processing and the addition of food preservatives which health experts say is not good for human health. William Pollan in his book, The Omnivore’s Dilemma, exposed to people the health risk they are exposing themselves to by eating American foods, which he says are full of chemicals. Pollan claims that most foods that Americans eat today be it meat, eggs, chicken, or milk comes from corn. According to Pollan, chicken, cows, fish, and turkey are all fed on corn (Pollan 4). However, his main concern is that the corn has certain ingredients that expose people to health risks. Some of the ingredients that come from corn include riglycerides, lecithin, the ci tric acid, and the mono-, the coloring and raspberry flavor. These ingredients are harmful to human health. In fact, some authors have claimed that the increased cases of chronic diseases such as heart attacks, cancer, diabetes, and obesity are attributable to the unhealthy foods that Americans eat, in the form of processed foods. ... Kenner begins by moving into various slaughterhouses and factory farms. While in a factory farm, he is amazed to observe how chickens are conditioned and fed on chemicals that make them grow too fast to move properly (Food Inc.). In another farm, he observes how cows are fed on toxic chemicals after which their products, such as meat and milk, are sneaked into the market by illegal immigrants, at an affordable cost. The filmmaker’s main concern is that Americans eat these unhealthy foods daily without knowing the health risks that they are exposing themselves to. Kenner concurs with Pollan’s observation that the rising cases of chronic diseases, such as heart diseases, cancer, diabetes, and obesity are largely to blame on the toxic chemicals that people eat in the processed foods and products from animals fed on toxic chemical substances. Industrial food is not only an American food as other countries, like China, are also increasingly becoming over obsessed with indust rial foods. According to the Eurominitor, a leading research firm in Europe, China will soon surpass America in terms of the consumption of industrial foods (Holt par. 1). In fact, the research firm predicts that China will become the number one consumer of processed foods by the year 2015. The Euromonitor states that China could consume as much as 107 million tons of processed foods compared to the 102 million tons consumed by the U.S. In fact, eating packed food is increasingly becoming a norm in the U.S. Holt noted that most Chinese foods come from animals fed on chemicals that make them grow and fasten too fast (par. 3). Since China has no any environmental

Sunday, November 17, 2019

Leadership and change Essay Example | Topics and Well Written Essays - 1250 words

Leadership and change - Essay Example All the employees presented such a feeling mainly due to neurosis or mental distress. This means, if an employee or employees are not mentally satisfied with the organizational culture or management strategies then such a situation arises. Not only this, maximum extent of co-workers reacted very roughly that lowered my perception towards them. Such a situation aroused mainly due to lack of communication or interpersonal skills. As the employees created a communicational gap within me and them, so their level of dedication and commitment towards the assigned goals also declined significantly. Along with this, the level of performance and productivity of the employees of my department also reduced that hampered the portfolio of the organization in the market. In addition, due to lack of dedication, our department failed to achieve the targets that hindered our reputation among other subsequent departments of the organization. Moreover, due to communicational gap, the other employees of our department failed to converse with me that hampered the operations and functions of the organization to a significant extent. As a result of which, the brand image and dominance of me, as a supervisor declined significantly that proved extremely worse for me and the organization. If a similar above mentioned situation is again faced by me, then I would organise a meeting with all my colleagues and interpersonally communicate with them. In that meeting, I would try to analyse and evaluate the strengths and weaknesses of each employee at the time of communication so as to reduce the gap among them. Apart from this, such an interpersonal communication might help the employees to communicate effectively with me that might enhance the motivational skills of both of us. This might prove effective in enhancement of the dedication power of the employees thereby amplifying their performance and efficiency at work. In addition, to enhance the

Friday, November 15, 2019

Answers to questions on the spread and control of diseases

Answers to questions on the spread and control of diseases List and discuss briefly major public health strategies for communicable disease control. Choose five communicable diseases and discuss what public health strategies will be appropriate in each case. Major Public Health Strategies for Communicable Disease Control The main public health strategies to control communicable diseases include all measures designed to prevent or reduce the incidence, prevalence and consequences of disease (WHO 1984). These measures are included in primary health care and involve participation of community, support from different government, public and private sectors and coordination between these sectors (WHO 1978). The control measures are directed against reservoir or sounce of infection, the root of transmission and susceptible host ( people at risk). i) Controlling Reservoir of Infection. It includes early diagnosis or detection of cases or carriers, notification of disease, isolation, treatment and quarantine. ii) Interrupting Transmission of Disease. This is done by interrupting direct transmission and indirect transmission of infective agent from patient and carrier to susceptible host by changing some part of mans environment. The public health strategies to achieve this includes clean water supply, improving sanitation, proper cooking and refrigeration, improving personal hygiene, controlling vectors and proper handling of secretions and excretions of humans and animals. iii) Protection of Susceptible Host or Patient at Risk This includes active immunization, passive immunization, combination of active and passive immunization and prophylaxis by drugs. iv) Other measures that have interrupted transmission of many diseases in developed countries include legislation for integrated and effective public health programs, improved quality of life and better education. Surveillance follows control measures. Five Communicable Diseases and Public Health Strategies to Control them 1-Chickenpox is acute highly infectious disease caused by varicella zooster virus (VZV) usually in children. It spreads by airborne particles and direct contact. The control strategies are notification, isolation of cases for six days after the rash appears, disinfection of articles soiled with secretion from nose, mouth and skin and using gloves and face mask while attending patient. Antiviral drugs are effective if used in first 24 hours of appearance of skin rash. Human varicella zoster immunoglobulin is given to contacts and immunocompromrised. A live attenuated vaccine is available and used in US and some other countries for children at one year of age. 2-Measles is acute highly infectious disease of childhood caused by a myxovirus. The control strategies include routine vaccine coverage of all children at 9 months and 4 years of age using live attenuated vaccine. Catch up vaccination is done for children who miss out. Successive generations of children are vaccinated. Isolation in initial stages of incubation period and disinfection of articles can help control spread. Notification to local health authorities, epidemiological investigation and health education are also necessary. 3-Diphtheria is caused by corynebacterium diphtheriae and affects upper respiratory tract. Control includes early detection of cases and carriers, notification, isolation in the hospital, and treatment of cases by diphtheria anti-toxin and carriers by erythromycin. Contacts are given booster dose of anti-toxin if they have not received in last two years and surveillance of close contacts is done for several weeks after exposure. On community bases the effective control is achieved by active immunization of diphtheria vaccine at age of six weeks, ten weeks, fourteen weeks, and booster doses sixteen to twenty-four months and five years. 4- Cholera is disease caused by vibrio cholera 01 (El Tor-most or Classical-less common). Main clinical manifestations are acute onset of diarrhea, massive fluid loss and shock. WHO guidelines for control of diarrhea (p192)(ref19) include verification of diagnosis from stool examination, notification to local health authorities, early case finding, establishing treatment centers, rehydration of patients, antibiotics like doxycylcline, OTC or ciprofloxacllin, epidemiological investigation, sanitation, use of clean water and properly cooked food, parental or oral vaccination and health education with diarrhea control program. 5-Enteric fevers include typhoid and paratyphoid fevers caused by Salmonella typhi and S.paratyphi A and B. Disease spreads by ingestion of contaminated faeces, urine, food, water and poor personal hygiene. Control measures includes control of reservoir by identification, isolation, treatment and disinfection; improving sanitation of food water and personal hygiene and using inactivated injectable vaccine and oral live attenuated vaccine. Q2 Select an infectious disease of your interest. Provide a comprehensive account of clinical features, diagnosis, causative organism, mode (s) of transmission. Explain past and current disease prevention techniques used to control the disease with an emphasis on primary and secondary prevention measures. Choose a country that is affected by that infectious disease described. Explain the disease burden, discuss relevant risk factors and discuss limitations or hurdles in the control and prevention of that disease. Answer Cholera i) Definition: WHO defines cholera as Cholera is an acute diarrhoeal infection caused by ingestion of food or water contaminated with the bacterium Vibrio cholera (WHO, Fact sheet on cholera 2010). Cholera is caused by vibrio cholera serotype 01. The El Tor bio type more commonly infects than classical bio type. ii) Pathogenesis: Enzyme adenyle cyclase is activated in intestinal wall by enterotoxin of vibrio cholera that activates cyclic-AMP leading to massive secretion of chloride and water from the intestinal endothelium.It infects both adults and children (Robbins, Stanley, Kumar, and Cotran 2010). iii) Clinical Features: Sudden onset of severe diarrhoea without pain, vomiting. Stool is like rice water in color. Severe dehydration, shock and oliguria. Death occurs due to circulatory failure. In most of the cases diarrhoea is mild and occassionally disease is very severe with intense loss of fluid and dilatation of intestine leading to death. It is dangerous when disease occurs in children (Boon, Nicholas, and Davidson 2006). iv) Diagnosis: During epidemic diagnosis can be made easily from clinical features. But confirmation of diagnosis requires laboratory methods. Specimen of stool is taken before anti-biotics are given. A fresh specimen of stool or rectal swabs are taken and transported via transport media or put in sterile container. In the laboratory direct microscopic examination with dark field illumination shows shooting star appearance of vibrio cholera against dark background. This test diagnosis in 80% cases of infection. Specimen can be cultured in bile salt agar medium over night and examined under oblique light for colonies. Serological tests like direct haemagglutination test and cholera phage type test are also available for phage typing (Robbins, Stanley, Kumar, and Cotran 2010) . v) Causative Organism: Cholera is caused by vibrio cholera (serogroups O1 and O139 are cause outbreaks), sero-type O1 causing the majority of the outbreaks, while serotype O139 causes less outbreaks and it is limited to South-East Asia. Other serotypes non-O1 and non-O139 cause mild disease only (WHO, Fact sheet on cholera 2010). vi) Modes of Transmission: Use of water contaminated with faeces from water wells, ponds, lakes and rivers for drinking purposes, consumption of contaminated food, drinks, vegetables, and fruits, ingesting cooked food, contaminated due to handling with contaminated hands and exposd to flies. Transmission also occurs due to direct person to person contact when one have contaminated hands and fomites. vii) Incubation period is from few hours to 2 days viii) Prevention: Traditionally the preventive measures include coordination between public and private sectors to achieve clean water supplies, proper disposal of excreta and waste water, safe handling of cooked food, drinks and other edibles protecting them from flies and conteminated hands, behaviroal modification and health education and knowledge about imporatance of personal hygiene. Currently two oral whole-cell killed vaccines Dukoral and Shanchol are commercially available. These are effective and provide more than 50% protection from vibrio cholera (WHO, Prevention and control of cholera outbreaks: WHO policy and recommendations 2008). Management: It includes replacement of fluid and electrolytes using intravenously ringer lactate when vomiting is present and oral fluids when there is no vomiting. Antibiotics, doxycycline 300mg or ciprofloxacillin 1gm or oxytetracycline 250 mg x 6hourly for 3 days reduces duration of diarrhoea and ammount of fluid loss (Boon, Nicholas, and Davidson 2006). Cholera in Zimbabwe The cholera epidemic in Zimbabwe began in August, 2008. According to WHO update June 9, 2009, cholera epidemic in Zimbabwe slowed down during 2009. The number of suspected cases of cholera was 98424 and number of deaths due to the epidemic reached 4276. According to the information given in this WHO report, 4.3% cholera patients have died due to cholera. The most of the reported cases of cholera (56%) affected Harare and its suburban areas, Beitbridge near South African border and Mudzi near Mozambique border. (WHO, Global Alert and Response 2009). Relavant risks factors are poor personal hygine, contaminated water and food, malnutrition, flies, migration, poverty and over crowding at camps.Limitations and hurdles to control cholera incude poor national efforts to find and control cases due to poor intersectorial coordination, political instabiity, emigaration of population, overcrowding near borders, insecurity and lack of resources for many immigrants to maintain proper food and sanitation, lack of health care providers and overstretched health care system. Q3 Investigate the effect of global warming on the patterns of three diseases of your choice. Look at where these diseases are now found considering where they were not 20 years ago. What has enabled these diseases to spread? (i.e. was it the increase in temperature, the spread of the vector, change to a different vector etc?). Answer Malaria Malaria is a parasitic infection and in humans it is caused by plasmodium falciparum, P.vivax , P.malarie and P.ovale and P.knowlesi. Malaria is transmitted when infected female Anopheline mosquito bites human. It occurs in tropical and sub-tropical areas below altitude of 1500 meters. According to WHO estimates 300-500 million cases of malaria occur every year in the world and more than one million people die annually because of malaria (WHO, Water-related Diseases 2010). Global Warming and Malaria: Global warming is leading to climate change in many regions of the world. There is increase in rains, rise in temperature and increased moisture that favors spread of insect vectors. This leads to increase in transmission of vector born diseases including malaria. Climate change or global warming is moving malaria to higher altitudes. Examples of spread of malaria are in highlands in Eastern part of Africa and Madagascar, Peoples Republic of Korea and the mountains of Papua New Guinea. These areas were malaria free 20 years back; are now experiencing seasonal epidemics. A model of predictions by Martens et al in 1995 showed that 3Â ° C increase in global temperature by 2100 will increase the annual malaria cases by 50-80 million (Martens et al., 1995). Causes of malaria spread: Environmental factors that help spread include temperature between 18Â ° C to 40Â ° C. At temperature lower than 16oC, development of plasmodium inside the mosquito stops. Humidity level of 60% is necessary for mosquito life. Rain provide breeding places. When a female Anopheline mosquito with sporozoites in her salivary glands bites human being it transmits malaria. Transfusion of blood containing malarial parasites and lack of prophylaxis can lead to spread of malaria. Prevention and Control : Chemoprophylaxis is achieved by chloroquine, malarone, doxycycline or mefloquine. Vector control strategies include indoor and outdoor spraying of insecticides, using insecticides treated nets and treatment of mosquito breeding sites with insecticides to eliminate them. The other measures are proper disposal of waste water and filling of waste water reservoirs (Boon, Nicholas, and Davidson 2006). Dengue In 1960 there was no case dengue fever, in 1990, the average number of cases reached above 400,000 and in 2005 the number reached above 900,000.In last twenty years geographical distribution of disease and number of cases have increased dramatically. The disease is endemic in south-east Asia, India, Africa, Caribbean and Americas (Mahr 2007). Causative Organism and vector: Causative organism is dengue flavi virus with four serotypes and all produce similar clinical syndrome. Principal vector is mosquito Aedes Aegypti but Aedes albopictus is also a vector in south-east Asian countries (Mahr 2007). Transmission: Reservoir of infection is man and mosquito. Transmission cycle includes man-mosquito-man. All ages and sexes are susceptible. Factors leading to spread of the disease: Increasing population and urbanization lead to improper management of water supply and water storage in open containers. The mosquito breeds in standing water. Air coolers using water and tyre dumps contain stagnant water and act as breeding sites. Global warming leading increased rains causing stagnant water pool thus cause spread of vector. In south-east Asia additional vector Aedes albopictus may also participate in spread of disease (Mahr 2007). Prevention: Main preventive strategies include abolishing Aedies mosquito breeding places and insecticide srpay to destroy adults. No vaccine is available (Boon, Nicholas, and Davidson 2006). Clinical features: Incubation period is 2-7 days. Disease can be asymptomatic but it is more severe in infants and elderly. Severe disease is called dengue haemorrhagic fever and causes circulatory failure and systemic complication. Main clinical features are continuous fever for 4-5 days, headache, severe body pains, pain in eyes, nausea, vomiting, diarrhea and skin rash. Complications like internal and external bleeding occurs(Boon, Nicholas, and Davidson 2006). Treatment: Symptomatic, fluid replacement and treatment of shock Japanese Encephaitis (JE) This is a mosquito-borne disease caused by Flavivirus. The vector is culicine mosquito. The disease predominantly affects children aged less than 15 years and has high fatality rate. Effect of global warming on spread of disease: This is a zoonotic disease that infects animals and occasionally human beings. The disease was endemic in Japan, China and Korea 25 years ago but now it is found in large population of South East Asia. The global warming has lead to changes in the environment of South East Asia with increased humidity and increase in rains. This has resulted in increased breeding places of mosquito and spread of disease(Boon, Nicholas, and Davidson 2006). Spread of Disease: Spread is through all serotypes of JE virus. The vector, culicine mosquito breeds in places containing water like rice water fields, water pools in jungles, ditches and fields. The reservoirs of virus are pigs and aquatic birds (Park 2008). Clinical Features: It is a systemic illness with fever, headache, vomiting, photophobia, seizures and paralysis. Control: By vector control using insecticide sprays in the fields, use of mosquito nets and vaccination of population at risk. Q4. Summaries of Readings Nelson K, Williams C. (2007): Early History of Infectious Disease: Epidemiology and Control of Infectious Diseases. In Infectious Disease Epidemiology Theory and Practice, 2nd edition. Jones and Bartlett Publishers, USA. This article describes early epidemics of infectious diseases in ancient civilizations, the gradual development of knowledge of infectious diseases and their control and development of public health measures and their role in infectious disease control in western civilizations. The ancient history of Greece and Egypt mentions epidemics of infectious diseases that killed kings as well as common people in large number. Political unrest and massive dislocation as a result of wars helped spread of diseases. From the writings of early historians researchers think these epidemics were due to smallpox, tuberculosis, diphtheria and meningococcal infection. The bubonic plague epidemics with other communicable disease caused wide spread epidemics in 160CE and 165-180CE in Europe leading demise of Hans and Roman empires and killing 5 million people. The plague epidemics occurred again in 12th and 14th centuries in Europe and killed massive number of Europeans. In cities people with better immunity survived. Small pox epidemic occurred in 14th century BCE in Egypt. Latter on it was disseminated in Europe. Wars and invasion disseminated it to Americas and killed hundreds of thousand people as they have no immunity against it. At that time it became known that skin lesio ns transmit disease and survivors were immune to re-infection. Deliberate exposure to disease was a practice used in China and India before its use in Europe. Hippocrates (460-377 BCE) in his treatise stated that environmental factors were responsible for occurrence of disease. Claudius Galen (131-201 CE) used ideas of Hippocrates and his knowledge of anatomy and physiology from animals and humans to describe his ideas in his writings. His writings were used in Europe till The Middle Ages. The contagious nature of infectious diseases were known but control measures were ineffective due to lack of knowledge of epidemiology. In case of plague, infected cases were quarantined and possessions and corpses were disposed off. The importance of rats and fleas in the epidemic of disease was not recognized. The lepers were considered as sinners during The Middle Ages. Fracastoro (1478-1553) presented the idea that transmission of infectious disease from one person to another was due to minute particles. The disease was transmitted by direct contact, by fomites and through air. The process of variolation, means intentionally inoculation people to induce immunity was advocated by scientists. Mather (1663-1728) described it in his slave. Edward Jenner (1749-1826) successfully inoculated cowpox in a boy to induce immunity against smallpox. This was first clinical trial of a vaccine. The small pox vaccination lead to its eradication two centuries later. Napoleon vaccinated his army against smallpox. Thomas Sydenham(1624-1689) advocated and differentiated various febrile illness by careful observation and many others adopted same strategy to describe illnesses including infectious diseases. John Snow (1813-1858) and William Budd (1868-1953) performed epidemiology of cholera and typhoid fever respectively before isolation of organisms. The other scientists started careful clinical observation, diagnosis and measure to control and treat patients. John Graunt(1620-1674) documented number and causes of death in London during a third of century, ratio of births and deaths of both sexes and these ratios in rural and urban areas and constructed life tables. The public health data was used to study infectious disease epidemics. It was also used to implement sanitary reform in London and proving cost-effectiveness of public health measures. Analytic use of public health data was introduced by William Far(1807-1883) Leeuwenhoek (1632-1723) invented microscope and described bacteria and spirochetes in fecal material and rain water. Louis Pasteur (1822-1895) showed that microorganisms cause fermentation and Robert Koch (1843-1910) showed microorganism cause disease. Later on other scientists discovered microorganisms as causative agents for various infectious diseases and the vectors responsible for transmission of causative agent. The yellow fever virus was discovered in 1898 by Reed. It was discovered that yellow fever virus is transmitted by mosquito Aedes aegypti. Malarial parasite was discovered by Alfonse Laveran in 1880. Ronald Ross discovered life cycle of avian malaria and Grassi discovered anopheline mosquito were vector for malaria and avian life cycle was same in humans. The knowledge of microorganisms that cause infectious diseases, the progress in bacteriology, immunology, virology, statistics have helped in understanding of epidemiology of infectious diseases. But still infectious diseases cause many deaths and outbreaks in various parts of the world every year. Discovery of penicillin by Alexander Fleming and subsequent development of various antibiotics has made treatment of infectious diseases possible. The public health officials and epidemiologists now assist health authorities in control of infectious diseases. Advancements in public health have increase the average life span of Infectious disease challenge: The advancements in genetics, virology and antiviral therapy had modified course of many infectious diseases. The older techniques of diagnosis and management of disease are being replaced with new ones. But still the challenge of infectious disease control remains ahead. Overview of the Control of Disease This article deals with control of infectious diseases during 20th century and challenges ahead during 21st century. During 20th century, there was decline in infant mortality that resulted 29.2 years increase of life expectancy. During 19th century, more than 30% deaths occurred in children under 5 years of age which dropped to 1.4% in 1997. In 1900, leading causes of death were pneumonia, tuberculosis diarrhea and enteritis. While in 1997, the main causes of death are heart disease and cancers. The decline in death rate during 20th century can be attributed to discoveries of 19th century like micro-organisms, improvements in sanitation and personal hygiene. The implementation of mass vaccination programs, invention of antibiotics, disease surveillance and control systems can be due to scientific advancements. Industrialization and mass movement of people towards cites during 19th century lead to epidemics of infectious diseases due to overcrowding, poor housing, poor person hygiene and poor sanitary measures. During 20th century chlorinated water supplies, proper waste disposal, better housing, better animal and pest control, use of disinfectants and application of sanitation measures in ships lead to decline infectious diseases. Mass vaccination programs caused fall in tuberculosis, diphtheria, tetanus and polio. Measles, mumps and rubella infections were also controlled. Vaccination Assistance Act helped continuous supply of childhood vaccines. Antibiotics and other antimicrobial drugs help control TB and other infections. Technological advances lead to serological testing and control of viral diseases. During 21st century continuous need of research into mortality and morbidity is needed to control and treat infectious diseases. Appearance of AIDS and some other infections show evolution in microbes. Molecular genetics show the appearance of drug resistant strains of microbes. For future success public health needs to address these and other upcoming challenges. Chase, A. (1982): Magic shots. William Morrow and Company Inc., New York. This article describes history of development of smallpox vaccine by Edward Jenner in 1796, the behavior of political, social, religious forces and scientists related to use of this vaccine in Europe and USA, the history of epidemics of smallpox, WHO campaigns for eradication of smallpox and finally eradication of smallpox. The Chinese and Indians knew before Christian era that material from smallpox lesions can be used to induce long lasting immunity in health individuals while Europeans lacked this knowledge. During 18th century the physicians in Western world started vaccinating affluent people with infected material from smallpox patients (called variolation) this caused active disease in 5-10% of variolated individuals, high mortality and severe complications. This led to banning of variolation practice in some US states. The smallpox was introduced into Europe as a result of Holy Crusade during first two centuries of second millennium. The crusaders infected with smallpox returned back to Europe and spread the disease. The smallpox existed in India, China, Egypt and Greece since thousands of years. Of and on epidemics killed hundreds of thousands of people and blinded and disfigured many due to complications. The smallpox was introduced to Americas by Spanish and European settlers. It was unknown there before so Native Americans did not have immunity against it. It resulted in numerous deaths devastating their civilizations. Edward Jenner, a Scottish physician noted that milk maids developed mild form of disease after they came in contact with lymph and secretions in the lesions of cows with cowpox. This was without complications and subsequently they became immune against smallpox. He was also aware that many people in cattle business inoculate themselves with lymph from cowpox pustules and become immune against smallpox. Jenner inoculated an eight year old boy with lymph from cowpox lesion (cowpox virus) by scratching his skin. The boy developed mild cowpox. After few weeks Jenner inoculated the same boy with lymph taken from smallpox patient, the boy did not developed smallpox. The inoculation of boy with lymph from other smallpox patient also did not cause smallpox in him. Jenner then repeated the experiment on other people and found that all developed immunity against smallpox after inoculation with lymph from cowpox. This was invention of a very safe and effective smallpox vaccine and beginning of immunology. Although during 18th CE smallpox was a major cause of death in Europe killing 15 million people every 25 years. Many influential people opposed use of Jenners smallpox vaccine due to various reasons. Industrial revolution resulted increase in population of poor areas of cities, sanitation issues and epidemics of all infectious diseases including smallpox. The English rich ruling class wanted Jenners vaccine for themselves and their families only. They allocated very small funds for its use in Ireland, and were against mass vaccination of public. The conservative religious riches considered saving poor from smallpox will disturb balance of nature and increase their population. The cost benefit analysis by experts was also used to show that mass vaccination was uneconomical. The English and French armies got vaccination against smallpox. Napoleon favored Jenners vaccine. Malthus and his supporters successfully opposed mass vaccination and other public health measures in Britain. Many of the colleagues opposed smallpox vaccination due to professional jealously with Jenner while other supported recognizing its benefits. The German and Scandinavian ruling class supported and implement ed mass vaccination during early part of 19th century decades before the English did so. In US Dr Benjamin Waterhouse a professor at Harvard visited Europe, became aware of smallpox vaccine and wrote President Thomas Jefferson, Vice-President at that time about the global eradication of smallpox. Jefferson agreed and appreciated the idea. The smallpox vaccine was imported and also prepared in US and small level vaccination was started. There were forces of opposition like England that slowed progress of vaccination. Shattuck Report in 1850 examined state of public health affairs in Massachusetts and stressed periodic vaccination of people along with all the sanitary measures. Immigrants from China and Europe, slaves from South and local poor provided cheap labor and were unable to afford proper housing and sanitation. They lived in crowded dwellings suitable for infectious disease epidemics including smallpox. The outbreaks occurred between 1820-1870 killing hundreds of thousand people. In Europe, during smallpox pandemic during 1870-1875, the dead rate in countries without compulsory vaccination was four times higher than those with compulsory vaccination Smallpox became internationally notifiable disease in 1926. WHO launched campaigns to eradicate smallpox from the world. First two campaigns failed but the third become successful and the last case of smallpox was reported in Somalia in 1977. Bureau of Smallpox Eradication became part of CDC in 1966 to endure safe vaccination against smallpox. The complications of smallpox vaccination are insignificant. World is global village and US and other countries can remain free of infectious diseases if they help less fortune countries to improve sanitation, overcrowding, personal hygiene, safe water supplies and other public health measures. Giesecke J. (2002). Mathematical models for Epidemics. In Modern Infectious Disease Epidemiology. London. Mathematical models are used in weather forecasting, economics and sociology. They are based upon certain assumptions, take more important factors as determinants of development and used for predictions and other protocols. These models are also useful in infectious disease epidemiology. Basic reproductive rate (Ro) gives average number of people who gets directly infected by an infectious case during infectious period in a susceptible population. During an epidemic current reproductive rate (R) is used. In an epidemic when R is greater than 1 shows disease will disappear when it is equal to 1, it will become endemic and when R is larger than 1 it becomes epidemic. When a proportion p of a population already immunized, p x R0 people will not catch infection and R p x R0 will be infected. Since epidemic occurs when R p x R0 is greater than 1so increasing secondary immunization level in a population increases value of p x R0 and epidemic does not occur. We can represent this relationship in a simple formula. R p x R0 (R0 -1) / R0 The determinants of Ro are risk of transmission per contact (ÃŽÂ ²), the number of contacts of an average person in a population (ÃŽÂ º) and during of infectivity of a person (D). Mathematically we can show the relationship Ro = ÃŽÂ ² x ÃŽÂ º x D The infections with high infectivity and longer immunity (childhood diseases), Ro estimation can be from average age at infection time. The formula R0 = 1 + L/A where L is average life span of a person and A is age when infection occurred. Researchers discuss a simple model of infectious disease making assumptions that disease occurs in a fixed population with zero latent period having duration of infectivity equal to clinical manifestation of disease. The population of size n can be divided into three proportions namely S, susceptible portion of n; I, currently infected and infectious proportion of n and R, immune proportion of n. Before infection S=1 while I and R are 0. With the spread of epidemic S decreases R increases and I first increases then decreases. Three equations can be setup and during epidemic these will be dS/dt = ÃŽÂ ² x ÃŽÂ º x S x I -(a) dI/dt = ÃŽÂ ² x ÃŽÂ º x S x I-I/D -(b) dR/dt =I/D-(c) Here eq.(a) shows proportion of susceptible people is decreasing. Eq (b) show

Wednesday, November 13, 2019

Impact of Technology in Australians Lives Essay -- Technology

From invitro fertilisation to autopsy, people’s lives in Australia are potentially subject to scrutiny. The extent to which details of a particular individual’s existence are on show depends not just on the person’s own decisions but also on the decisions of related others, private firms and the state as well as inadvertent access by technology. This essay examines several points in people’s lives where they are most likely to encounter the public gaze, either now or into the future. Specifically, these junctures are the Census, The 100 point ID system and the lens of telepanoramic digital photography. Every five years, the Census provides a snapshot of Australian households. The data collected forms the basis of public planning. (How to complete your Census form 2006, p.2) On the night of August the 8th 2006, Australian households undertook the latest census. The form could be completed in either hard copy or online. Of particular interest was Question 60, Time capsule, which invited households to have a copy of their responses to the Census identified by their names in microfilm format for future reference. This information will be held in secure storage by the National Archives of Australia for 99 years when it will be made available to ‘genealogists †¦, historians, academics, social analysts, journalists, and fiction and non-fiction writers’. This option was first made available at the previous Census held in 2001 (How to complete your Census form 2006, p.17). This opportunity was welcomed by genealogists, who have long envied their British counterparts historic and full access to census data from 1841 onwards. Indeed, the 1901 census has recently been made available (Census Online 2006). In the Australian case however, t... ...to complete your census form 2006 Australian Bureau of Statistics, Canberra. The metroguide: a guide to Adelaide’s public transport system n.d. Adelaide Metro, Adelaide. Murray, E 2006 ‘Jail for â€Å"greedy† con woman’, The Age, September 22. Viewed 19th of October 2006 Norris, M 2006 ‘I caught our most-wanted con woman’, Woman’s Day, October 2006, pp.34-35. Privacy on the Internet: Effect on genealogy n.d. Viewed 12 October 2006 Tadros, E & Petrie, A 2006 ‘Moment of truth in the many lives of Jodie’, The Sydney Morning Herald, July 7. Viewed 19th of October 2006 Whittaker, N 1998 Controlling your credit cards, Simon & Schuster, East Roseville.

Sunday, November 10, 2019

Foundations of Human Development in the Social Environment

The foundation of human development, responds to the breakdown of its commitment to the development of attitudes and skills, which facilitate authentic personal, spiritual, and social development and the transformation throughout an individual’s life span. During an individual’s life span, the foundations of human development begin to change, as the direct result of the social environment. Contact within the social environment, such as various relationships with others, causes growth and change in human development.The understanding of culture and the importance of cultural competency are major factors in the development of humans in a social environment. Various aspects of development are combined together to make up an individual’s growth and development. The basics of human development in the social environment must focus on the dynamic interactions among biological, psychological, and social aspects of development. The understanding of human development requi res the comprehension of the various ranges of issues, people are facing as they continue progressing in life.This understanding includes the entire life span of an individual. The life span includes infancy, childhood, adolescence, and adulthood. Each individual may face different situations in each of the different groups of the life span, which could cause alternative responses depending on physical appearance, knowledge base, or even socializing. The focus of understanding of human development in the social environment includes these three theories, biological development, psychological development, and social development.These signs of development together can be referred to as bio-psycho-social development. Biological development includes the physical aspects of the individual’s personal life. Psychological development is the individuals functioning and cognitive processes. The social development brings out the individuals interaction with others around them. In this er a, diversity and cultural competence are extremely important to understand, regarding the foundations of human development in the social environment. Diversity can alter or affect an individual’s behavior in many ways.Diversity is considered when an individual is different, or composed of differing elements. Therefore, diversity can include different nationality, gender, sexual orientation, age, class, disability, gender identity, immigration status, political ideology, and religion. At any time, an individual is determined as belonging to another group, different from the majority, the individual is considered to be subject to the effects of diversity. Many children coming from different countries have a problem with language.Not being able to speak the language of the community can cause huge barriers for the children to overcome. Many parents believe that the key to a successful life and fulfillment is to get an education. These parents encourage their kids, that with an e ducation nothing can defeat you. It is also very important for the social worker, or human service provider to be comfortable with diversity, and is culturally competent. Cross-cultured means the individual appreciates and compares the differences and the similarities of different cultures as well as their own.The general systems theory based on order, explains why the scenario is what it is. The study of social systems perspective gives the identified assumption that there is an underlying intelligible general order in the world to which all matter relates. Therefore, social order is a subset of general systems, and works together to form the theory of order. General systems theory has become more than just a theory; it has become a way of life, and a part of how we communicate.This system begins by using a reduction method, breaking down the individual by parts, which is what we may call simplification. This idea ensures each part of the whole is more manageable, and understandabl e. In this conclusion, the human development in the social environment can be changed by the stimuli of the environment or subjects surrounding them. The interaction between the bio-psycho-social dimensions of development, the concept of human diversity, and the cultural competence are all part of the general systems theory and social order.Explaining the reason why we do the things we do, challenges we face while pursuing our goals, and the changes in our personality and human development in regards to our social environment. Although, there are many factors that affect individuals as they pursue a life full of dreams, one thing is for sure, education is very important, and the environment in which an individual surrounds himself or herself with will influence decision, actions, and development of each individual.

Friday, November 8, 2019

feminism and the private spher essays

feminism and the private spher essays By recognising that politics is a science not only of the public realm but also of the private, feminism shows itself to be an ideology that challenges conventional thought. As the question rightly states, it is feminists imparticular that oppose the division but this view has influenced many others to think in such a way about the public and private. In short, feminists believe that the plight of women can only be eased if the private sphere is opened up to political debate. Feminists have stated on numerous occasions that the main way in which they are oppressed is within the private sphere. It is thought that men are able to stunt the progress of women through psycologically degrading them in the home. By doing this, in the private realm, women do not have the confidence (or permission) to perform a role in the public realm. Feminists argue that wife-beating and rape within the home are common ways of degrading women. The current division we have between the public and private means that the state is powerless to address the issue, seeing as it is an issue outside the public sphere. Political intervention is essential for this issue, hence the division needs to disappear. It should be noted also that this hypothesis applies to any weak groups within society, such as the disabled, Feminists also oppose the division between public and private because of mens domination in the public sphere. All state institutions in the UK are inhabited overwhealmingly by men; the House of Commons has less than a sixth of its members that are female. Art and literature are still male-orientated disciplines. The point is that when there is a time (like now) where women are equal in name to men, it has very little meaning to women as they are equal only in a male designed world. The Greek playwright Euripides once suggested that women would only be equal when they have ...

Wednesday, November 6, 2019

Answer Why Has Reverend Hale Returned to Salem

Answer Why Has Reverend Hale Returned to Salem SAT / ACT Prep Online Guides and Tips A lot of readers of The Crucible have the same question: why has Reverend Hale returned to Salem in Act 4?This is a short article detailing the reasons behind Hale's decision to return.If you're confused about what his motivations are and what he hopes to accomplish, read on for a complete explanation. Why Is This Question Tricky? At the end of Act 3, Reverend Hale quits the court in Salem out of frustration because he sees that irrationality and hysteria have taken over the proceedings. However, in Act 4, we learn that he has returned to Salem to speak with the prisoners and convince them to confess. This is a bit confusing - why would he return to Salem to convince people to confess if he believes that they're innocent? As I'll explain in the next two sections, Hale has shifted his moral compass slightly to accomodate his own guilt. Guilt and its counterpart, concern for reputation, are both common themes in The Crucible, which makes understanding the answer to this question important for an effective reading of the play. Short Answer Hale has returned to Salem in Act 4 because he recognizes himself as the original instigator of the ultimately unfounded witch hysteria, and he doesn’t want to end up with the blood of innocent people on his hands (or at least innocent people who are widely respected like Rebecca Nurse and John Proctor).His goal is to persuade the condemned prisoners to sign their names to false confessions. Hale has managed to convince himself that lying is a lesser evil than throwing away one's life for the sake of maintaining a spotless record of integrity. This is a somewhat selfish viewpoint, although it's the only one he can accomodate psychologically. If he gets the prisoners to save their own lives, his positive self-image will not be marred by their executions.He fails to fully consider the negative impact a confession would have on the self-image of the confessor, which is why no one responds to his efforts. Long Answer Reverend Hale’s purpose in returning to Salem is to speak with the condemned prisoners and convince them that they should give false confessions rather than martyr themselves.He chooses to do this because he is tormented by guilt.When Danforth asks Hale directly why he has returned, Hale responds, â€Å"Why, it is all simple. I come to do the Devil’s work. I come to counsel Christians they should belie themselves. There is blood on my head! Can you not see there is blood on my head!!† (Act 4 pg. 121). Note that when Hale says he comes to do "the Devil's work," he is being sardonic. He knows that what he's doing is technically not befitting of a man of God, but he feels that promoting lies is better than the alternative of allowing innocent people to go to their deaths because of him. He feels responsible for the way things played out in Salem since he was the original â€Å"expert† called on to investigate the witchcraft rumors in Act 1. He lit the fuse by pressuring Abigail to answer leading questions about her activities in the woods (pg. 40), prompting her accusations against Tituba.He then ignored Tituba’s protests that she never called the Devil (pg. 41) and insisted that she name the names of other people she’d seen with Him (pg. 44).He had all the authority in that situation because of his supposed superior knowledge of witchcraft (pg. 37), and he used it to intimidate people into confessing. This initial storm of confessions and ensuing hysteria eventually led to the condemnation of people he knew to be innocent.He signed seventy-two death warrants (pg. 92), including that of Rebecca Nurse, based on what he now believes was false evidence.The only way Hale thinks he can make up for this is by returning to Salem and convincing the accused to save their own lives, even if they must lie to do so.He’d rather advocate lying than be responsible for the deaths of innocent people.He does not consider that signing a confession is essentially the same as death to someone like Rebecca Nurse, whose whole identity is based on her integrity and piousness. Hale is ultimately only looking out for his own peace of mind and spiritual wellbeing. And God did say unto Reverend Hale, "#yolo." Summary:Why Has Reverend Hale Returned to Salem? Here's a short bullet point recap of the answer to this question: Hale returns to Salem to convince the condemned prisoners to confess to witchcraft. He does so because he feels responsible for the miscarriage of justice that led them to their current situation. He knows it's too late for them to be pardoned, so persuading them to give false confessions rather than hang is the best way to clear his own conscience. What's Next? So what actually happens in Act 4? What does the ending of the play mean? Check out our full summary of the last act of The Crucible. If you want to back up a little bit to the heightened courtroom drama of Act 3, you can also read our full Act 3 summary, complete with key quotes and thematic analyses. Another tricky question that comes up in The Crucible is why Elizabeth wants John to go to Salem in Act 2. Read our answer and explanation. Want to improve your SAT score by 160 points or your ACT score by 4 points?We've written a guide for each test about the top 5 strategies you must be using to have a shot at improving your score. Download it for free now:

Sunday, November 3, 2019

Preparing to Conduct Business Research Paper Example | Topics and Well Written Essays - 750 words

Preparing to Conduct Business - Research Paper Example The organization chart should focus on specific roles and responsibilities instead of individual workers. If the organizational structure does not exist it means that job duties, roles and responsibilities are frequently neglected. If the gap in responsibilities exist than no one will acknowledge the accountability part or take the responsibilities of their duties, instead they will be pointing fingers. Basically the gap is the one thing which leads the company to identify the areas in the organization which require improvement. This improvement may include training and development of a single employee or it might include the restructuring of a whole department or more than one department. If the organization lacks a structure, the productivity and efficiency of the organization can suffer a lot as the basic factor of accountability is missing. If the organization lacks a structure or if it is weak, conflicts can arise because employees are not clearly informed about their job description, which includes the job duties and job responsibilities. Conflicts can occur as everyone will put the task on the shoulder of other employee as no one knows who has to perform it or how it will get done. Another cause which can lead to conflict is that when people having no authority tend to seek control in the organization. Due to this reason many responsibilities and roles can suffer including managerial and non-managerial as the organizational hierarchy doesn’t exist. The whole effect of the problem that occurs due to lack of organizational structure results in reduced productivity and poor operations which lead to low profitability. As the responsibilities are not clear to management individuals or management teams, everyone lacks coordination and right direction to generate profits (Hill and Jones, 2010). Here we can also say the strategic management part is absent in

Friday, November 1, 2019

Marketing Plan Research Paper Example | Topics and Well Written Essays - 2000 words - 3

Marketing Plan - Research Paper Example Other areas of specialization in which the company invests in are beverages, which are used worldwide. Besides the operations of the company within the UK market, the company has major markets within the US, Germany, Italy, Japan, Spain as well as in France. GlaxoSmithKline Plc as a trading company has a statement of mission, which is ‘provision and development of immunotherapeutic, as well as vaccines that are necessary for improvement of human health globally’. The company has made strategic milestones in the field over years and is credited for having great and contributions towards the global health as it is today. The company’s profile reveals that the formation of the company as it is today has involved merger efforts with many companies and thus would have a history from the early years of 20th century. The existence of the corporate identity of GlaxoSmithKline plc is not that old s it dates from the time of merger of SmithKline Beecham and Glaxo Wellcome in December 1999 (Addison & Lawson, 2012). GSK has special attention on such fundamental areas as realizing sustainable growth, improving long-term financial performances as well as reducing risks. It realizes these goals through embracing diversification, developing and delivering high-value products as well as adoption of simplified business models. The recent developments have seen the company adopt generic branded manufacturing to add to the previously existing patented strategies in order to command higher influence and relevance in the modern day market. Addison and Lawson through a recent discourse analysis study concerning the strategic development move of generic branding found out that this was necessary and very effective in lowering the associated performance risks as well as in increasing the range of products being traded on. The shift in production models into the incorporation of generic manufacturing has greatly revolutionized the industry through lowering